Stock Downgrades: Anheuser-Busch Set For Friday Night Hangover ...

Yesterday?s?Dow?(^DJI) increase of only 24.50 points may not have been anything on the excitement of exactly six years earlier, but it?ll do for now.
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Strange bedfellows dominated the day, what with?Jimmy Carter gushing over George Bush?and the Wall Street Journal turning over its editorial page?to a New York Times (NYT) journalist who did jail time. (Such a selfless gesture from right wing to left, and on?Pay It Forward Day?no less, sent shares of the Old Grey Lady surging some 5.00%.)
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Elsewhere Kentucky Fried Chicken owner?Yum Brands?(YUM), which jumped 7.10% on Wednesday and scored an?analyst upgrade 24 hours later, tumbled 2.11% after it became apparent that?Colonel Sanders? favorite food was actually?White Castle.
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Today in economics, consensus says April?s University of Michigan consumer sentiment survey will show an improvement at 9:55 a.m. Eastern. Peak earnings week concludes with announcements expected out of?Alcatel-Lucent?(ALU),?Burger King (BKW), Chevron (CVX), DR Horton (DHI),?Goodyear Tire?(GT),?Honda Motor?(HMC),?LyondellBasell (LYB), Total SA?(TOT),?Tyco International (TYC),?VF Corporation (VFC), and?WellPoint?(WLP).
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Alkermes?(ALKS): The stock is downgraded to Underperform from Neutral at Bank of America-Merrill Lynch.
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AmerisourceBergen?(ABC): Shares are now Neutral from Outperform at Robert W. Baird, which trims its target to $57 from $59 after a recent run to record highs.
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Anheuser-Busch?(NYSE:BUD): The brewing behemoth is slashed to Conviction Sell ? surely the ultimate ignominy ? from merely Sell at Goldman Sachs. Shares are lower in today?s pre-market trading as a result.
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Baidu Inc.?(BIDU): Shares in the Chinese Internet outfit, imploding 8% before the opening bell, get downgraded to Hold from Buy at Brean Capital.
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Beneficial Mutual Bancorp?(BNCL): The name is now Neutral from Buy at Sterne Agee.
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Carpenter Technology?(CRS): CRS gets cut to Neutral from Overweight at JPMorgan.
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Duke Realty?(DRE): The stock is moved to Market Perform from Outperform by BMO Capital.
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Embraer?(ERJ): Shares are slashed to Sell from Neutral at Citigroup.
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Exxon Mobil?(XOM): The oil giant and key?Dow?(^DJI) component is now Neutral from Buy at ISI Group.
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F5 Networks?(FFIV): Shares are downgraded to Perform from Outperform at FBR Capital, which notes competitive threats from Intel (INTC) among others.
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Hancock Holding?(HBHC): The stock is now Hold from Buy with Wunderlich.
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ITT Educational Services?(ESI): The stock is downgraded to Sell from Neutral at Compass Point.
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KLA-Tencor?(KLAC): KLAC gets cut to Outperform from Buy at CLSA.
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Raymond James Financial?(RJF): Citigroup reduces its recommendation on RJF to Neutral from Buy.
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Windstream?(WIN): The equity is now Neutral from Buy at Bank of America-Merrill.

(See also: New Stock Coverage: TherapeuticsMD Is Just What the Doctor Ordered and Stock Upgrades: Don?t Throw Bebe Out With the Bath Water.)

No positions in stocks mentioned.

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Source: http://www.minyanville.com/trading-and-investing/stocks/articles/Stock-Downgrades253A-Anheuser-Busch-Set-For/4/26/2013/id/49500

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Battery of tests on cancer cells shows them as 'squishy,' yet tactically strong

Apr. 26, 2013 ? A team of student researchers and their professors from 20 laboratories around the country have gotten a new view of cancer cells. The work could shed light on the transforming physical properties of these cells as they metastasize, said Jack R. Staunton, a Ph.D. candidate at Arizona State University in the lab of Prof. Robert Ros, and the lead author of a paper reporting on the topic.

Metastasis is a critical step in the progression of cancer. It is when the cancer spreads from one organ or part to another. While much is known about metastasis, it remains an incomplete understanding of the physical biology of the transition.

To get a better understanding of metastasis, more than 95 graduate students, post docs and professors in a variety of laboratories across the U.S. subjected two cell lines to a battery of high-tech tests and measurements. Their results were published April 26, 2013 in Scientific Reports.

The researchers performed coordinated molecular and biophysical studies of non-malignant and metastatic breast cell lines to learn more about what happens to a cell when it transitions to a metastatic state.

Each laboratory is part of the National Cancer Institute's Physical Sciences Oncology Center (PSOC), a network of 12 centers devoted to understanding the physical sciences of cancer. ASU's center, the Center for the Convergence of Physical Science and Cancer Biology, is led by Prof. Paul Davies.

Each PS-OC was supplied with identical cell lines and common reagents, and considerable effort was made to ensure that all the conditions were standardized and documented at regular intervals. Staunton said the ASU group made three contributions to the study.

Other ASU researchers involved in the project and co-authors on the paper are: Alexander Fuhrmann, Vivek Nandakumar, Laimonas Kelbauskas, Patti Senechal, Courtney Hemphill, Roger H. Johnson and Deirdre Meldrum.

"We compared the stiffness of normal breast cells and highly metastatic breast cancer cells, and found the cancer cells to be significantly more 'squishy' or deformable," Staunton said. "This makes sense because in order for a cell to metastasize, it has to squeeze through tight passages in the lymphatics and microvasculature, so being squishy helps cancer cells spread through the body."

"We also looked at the morphology of their nuclei," he added. "The cancer cell nuclei were found to have a characteristic 'crushed beach-ball' shape that might correspond to the abnormal chromosomal rearrangements associated with cancer."

"Finally, we took individual cells, put each one in an airtight chamber, and measured how much oxygen they consumed," Staunton said. "This tells us about their metabolism. We found the cancer cells use less oxygen, relying more on glycolysis, kind of like what bacteria and yeast do."

Taken together, researchers at the 12 PSOC's used some 20 distinct techniques, including atomic force microscopy, ballistic intracellular nano-rheology, cell surface receptor expression levels, differential interference contrast microscopy, micro-patterning and extracellular matrix secretion, and traction force microscopy.

The work has enabled a comprehensive cataloging and comparison of the physical characteristics of non-malignant and metastatic cells, and the molecular signatures associated with those characteristics. This made it possible to identify unique relationships between observations, Staunton said.

"We were surprised that even though the cancer cells are softer, they are able to exert more contractile forces on the fibers surrounding them -- which was determined at the Cornell University PSOC by a method called traction force microscopy. This pair of characteristics is somewhat contradictory from a purely physical perspective, but it makes sense for a cancer cell, since both traits improve their chances of metastasizing. Understanding why is still an active area of research," explained Staunton, who is working towards his doctorate in physics.

"Another interesting finding was that a protein called CD44, which doubles as a cancer stem cell marker and as a molecule that helps the cell stick to certain fibers in the extracellular matrix, is equally abundant in the normal and cancer cells. But in the cancer cells the proteins don't make it to the cell surface," he added.

"For some reason they stay inside the cytoplasm, so the cancer cells are not as sticky," added Staunton whose hometown is Buffalo, N.Y. "This is another trait that contributes to their ability to spread through the body."

The PSOC network went to great lengths to have all of the studies performed under comparable conditions. While the cell lines studied are well understood, part of the effort for the network was to prove they could consistently coordinate the research.

Staunton, who has been involved in ASU's center since its inception, says the experience has helped his growth as a researcher.

"It is the perfect habitat for budding scientists and for transdisciplinary collaborations," he said.

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The above story is reprinted from materials provided by Arizona State University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. David B. Agus, Jenolyn F. Alexander, Wadih Arap, Shashanka Ashili, Joseph E. Aslan, Robert H. Austin, Vadim Backman, Kelly J. Bethel, Richard Bonneau, Wei-Chiang Chen, Chira Chen-Tanyolac, Nathan C. Choi, Steven A. Curley, Matthew Dallas, Dhwanil Damania, Paul C. W. Davies, Paolo Decuzzi, Laura Dickinson, Luis Estevez-Salmeron, Veronica Estrella, Mauro Ferrari, Claudia Fischbach, Jasmine Foo, Stephanie I. Fraley, Christian Frantz, Alexander Fuhrmann, Philippe Gascard, Robert A. Gatenby, Yue Geng, Sharon Gerecht, Robert J. Gillies, Biana Godin, William M. Grady, Alex Greenfield, Courtney Hemphill, Barbara L. Hempstead, Abigail Hielscher, W. Daniel Hillis, Eric C. Holland, Arig Ibrahim-Hashim, Tyler Jacks, Roger H. Johnson, Ahyoung Joo, Jonathan E. Katz, Laimonas Kelbauskas, Carl Kesselman, Michael R. King, Konstantinos Konstantopoulos, Casey M. Kraning-Rush, Peter Kuhn, Kevin Kung, Brian Kwee, Johnathon N. Lakins, Guillaume Lambert, David Liao, Jonathan D. Licht, Jan T. Liphardt, Liyu Liu, Mark C. Lloyd, Anna Lyubimova, Parag Mallick, John Marko, Owen J. T. McCarty, Deirdre R. Meldrum, Franziska Michor, Shannon M. Mumenthaler, Vivek Nandakumar, Thomas V. O?Halloran, Steve Oh, Renata Pasqualini, Matthew J. Paszek, Kevin G. Philips, Christopher S. Poultney, Kuldeepsinh Rana, Cynthia A. Reinhart-King, Robert Ros, Gregg L. Semenza, Patti Senechal, Michael L. Shuler, Srimeenakshi Srinivasan, Jack R. Staunton, Yolanda Stypula, Hariharan Subramanian, Thea D. Tlsty, Garth W. Tormoen, Yiider Tseng, Alexander van Oudenaarden, Scott S. Verbridge, Jenny C. Wan, Valerie M. Weaver, Jonathan Widom, Christine Will, Denis Wirtz, Jonathan Wojtkowiak, Pei-Hsun Wu. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports, 2013; 3 DOI: 10.1038/srep01449

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/bVQjS3PQ97M/130426135034.htm

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Clues to making vaccine for infant respiratory illness

Apr. 25, 2013 ? An atomic-level snapshot of a respiratory syncytial virus (RSV) protein bound to a human antibody represents a leap toward developing a vaccine for a common -- and sometimes very serious -- childhood disease. The findings, by scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, define the vulnerable shape of a critical RSV component called the fusion glycoprotein.

The NIAID scientists determined the fusion glycoprotein's shape as it appears before its interaction with human cells. It is this pre-fusion shape that is most vulnerable to neutralizing antibodies. Progress toward an RSV vaccine has been stalled in part because researchers did not previously know about a highly vulnerable site at the tip of the pre-fusion form of the fusion glycoprotein. Now that the structure has been solved and the site of antibody vulnerability revealed, scientists can use the new structural information to design vaccines capable of eliciting potent antibodies aimed at the target on top of the pre-fusion state of the glycoprotein.

Almost everyone is infected with RSV before turning three years of age. Most children recover quickly from such symptoms as sneezing, runny nose and cough, but the virus is a leading cause of hospitalization in children under age one. In the United States each year between 75,000 and 125,000 children in this age group are hospitalized with RSV infection. Globally, RSV infection accounts for nearly 7percent of deaths among children between the age of one month and one year. The only drug available to prevent severe RSV illness is a monoclonal antibody, palivizumab, which binds to the RSV fusion glycoprotein.

In their study, the NIAID researchers showed how three antibodies that potently neutralize RSV all bind to the newly revealed site on the fusion glycoprotein of RSV. Thus, in addition to new clues for vaccine developers, the NIAID findings also provide a structural basis for how these antibodies neutralize RSV. This insight could accelerate development of these antibodies into therapies to treat or prevent severe RSV disease in very young infants, who are the most vulnerable to serious illness.

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Story Source:

The above story is reprinted from materials provided by NIH/National Institute of Allergy and Infectious Diseases, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Jason S. McLellan, Man Chen, Sherman Leung, Kevin W. Graepel, Xiulian Du, Yongping Yang, Tongqing Zhou, Ulrich Baxa, Etsuko Yasuda, Tim Beaumont, Azad Kumar, Kayvon Modjarrad, Zizheng Zheng, Min Zhao, Ningshao Xia, Peter D. Kwong, and Barney S. Graham. Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody. Science, 25 April 2013 DOI: 10.1126/science.1234914

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/4ZGhrONTNNI/130425142434.htm

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Living with Google Glass, Day One: the reveal

In a loft atop Chelsea Market, Google is doing something special. Here, lucky Explorers will get their first taste of Project Glass. Yes, Google's latest X project (that we know about, at least) has finally made its way to the East Coast en masse. More importantly, it's also made its way to my face. A full Engadget review of the headset is most certainly on the way, but this is the sort of thing that will take some time to evaluate. You can quite quickly size up the next iteration of a great smartphone. Evaluating a wholly new product category to see how it fits into your life? That takes a little longer, dear readers.

I plan to spend a little while living with Glass in a variety of ways, some exciting and many less so, with the goal of getting comfortable with the thing -- or uncomfortable, if that's how it turns out. Given how many of you are excited to read about Google's new wearable, we wanted to let you come along for the ride. After all, isn't sharing an experience what Glass is really all about? Join me for my very first impressions after picking up my headset and some sample footage of the trip home.

Gallery: Google Glass unboxing

Filed under: Wearables, Google

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/u2bUDZk_glM/

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Google Brings Its New And Improved File Viewer For MS Office Documents To Chrome Beta

If you regularly need to open Microsoft Office documents in the browser, Google now offers you a new Chrome extension that renders Word, Excel and PowerPoint files directly in the browser. Currently, these documents open in a Drive-based viewer, but after you install the new Chrome Office Viewer (which is officially still in beta), these documents will open directly in the browser. Until now, this feature was limited to Chromebooks, but now it’s also available for Chrome on Windows and Mac. You do need to run Chrome Beta, however, as it’s not available for the stable release channel of Chrome just yet. The advantage of this new plug-in (which weighs in at over 20 megabytes), Google says, is that it ensures that you are protected from malware because the files open in a specialized sandbox “to impede attackers who use compromised Office files to try to steal private information or monitor your activities.” While Google doesn’t say so in today’s announcement, chances are this new feature is at least partially powered by the technology it acquired when it bought Quickoffice last year. When Google launched the Pixel Chromebook in February, it also said it would port Quickoffice to Chrome, using its Native Client technology. Those three months are almost over, so we’ll likely see a bit more from Google with regard to Office documents in the browser.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/2UTTJYJG7Zs/

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Senate deal reached on FAA furlough bill

WASHINGTON (AP) ? With flight delays mounting, the Senate has passed legislation to end air traffic controller furloughs blamed for inconveniencing large numbers of travelers.

Approval came without dissent, and long after many senators had left the Capitol for a weeklong vacation.

A House vote is expected as early as Friday.

Under the measure, the Federal Aviation Administration would gain authority to transfer up to $253 million from accounts that are flush into other programs, to "prevent reduced operations and staffing" through the Sept. 30 end of the fiscal year.

Officials said that would likely be enough to restore full staffing for the furloughed controllers, as well as prevent the closure of small airport towers.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-25-FAA-Furloughs/id-afd44c5716c74d678626a265bc1f035b

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Boston blast investigators identify a face

>>> we will find out and we will hold accountable and bring to justice whoever is responsible. but this investigation is now not even 48 hours old and it is important that we maintain the integrity of the investigation.

>> today, the fbi first postponed and then canceled their regular briefing on the investigation into the boston marathon bombing. authorities told ncbc news that authorities have a face but not the name of someone seen on camera. they just have the face. someone dropping a black bag near the second blast site. an official says investigators are zeroing in on some people. joining me now is nbc news national investigative correspondent michael isikoff and agent james calf nau. how did the news media get out of control on this, some of the other networks saying they had an arrest and then how did that in any way possibly lead to the canceling of the regular briefing?

>> we don't know for sure. and it's too bad because it would have been good to clear up what's become a confusing situation but my sense is, some investigators got pretty excited about these surveillance photos, that they were able to identify somebody who they thought had left off a bag at the bomb site that could have been the bomb. they were helped very much by the footage they got in from the camera at the lord & taylor department store , a few hundred yards down the road here. and that led to a lot of excitement and hopes that there had been a major breakthrough. it's not clear how big of a breakthrough it is. clearly it's progress. clearly they've got something to work with. but i'm -- we're reporting tonight that they've distributed -- the fbi is distributing a photo image of the individual to other federal law enforcement agencies asking for them to help in helping to identify this individual. it's a pretty good indication they don't know at this moment who that is. and so this could still be yet quite an arduous task without a name who they are looking for. they don't know who they are looking for and beyond that, they don't know that that person is necessarily connected to the bombing. they know that they've got surveillance photo that is suggestive and raises questions and they want answers. but we're still pretty far off from getting a real breakthrough in this case.

>> james cavanaugh , an asset that the fbi and police do not have is the ability to trace gunpowder. why do they not have that ability now?

>> that was blocked in the '70s. these were little taggants, the size of a period on a piece of paper. i was around at the time, we trained with them, they were magnetic and they would glow in the dark . we would go out with magnets, special gloves, black lights , and we could actually recover these taggants after a bomb detonated and be able to tell us the date shift code, which is basically the lot and serial number of a batch of dynamite. we were very excited about it. we sent some of those explosives into the field, a homicide case was solved in the baltimore division with it but eventually when it got to the hill, gun lobby got involved, basically said, you know, if you let the atf tag explosives, next they are going to tag the powder and then road den drons and whatever. it hurt many bombing cases which is atf is particularly interested in solving 40 years ago and through today.

>> and james , where do you think this investigation would be tonight were it not for the nra's blocking that particular investigative tool?

>> well, in theory, lawrence, it could have given us a lot number. in theory, that's possible. you know, when you're working on a difficult case like this as mike described, every little bit of information can help you build the case. but you just had the governor on and i just want to i sa, this case from afar was being well run. this task force was tight, despite what happened today in the media, this task force is great. you can see the way it's been running. i've been involved in many of these cases. the agencies, boston police , boston police bomb squad , detective bureau right on through the state police , immigration, u.s. attorney , and i've worked with governor patrick. he flew to alabama and worked with me on the church fires. he's a good leader. they are doing a great job and they are going to break the case.

>> james , do you have any insight as to why this briefing would have been canceled today?

>> i think the commanders are probably at a decision point on whether or not they are going to further release the images. meek talked about it and he's exactly right. you know, you have an image, it could be very significant to identify a person or not. let me give you an example. in the eric rudolph case, we had a photograph of eric rudolph with the alice pack , with a backpack, with a bomb in it at olympic park but the photograph was so distant, we could hardly make him out. we used to call them in the command post , blob man, because we could see him threw but couldn't make out the features. we had that image for years but were never able to get an identification from it. so the clarity of the video, is the face available, is the clothes readily recognizable. the commanders are trying to make all of those decisions carefully. and i would say this. i try to release it in a tight circle to see if i can get something first and then start making the decision, i wouldn't want to start holding that too long if i thought i could get to the identity of the guy or perpetrators by releasing to the public. because the main thing is to catch these bombers before they strike again.

>> michael isikoff , it seems that the next fbi briefing will, for some number of minutes anyway, be bogged down in the procedural question of why did you cancel the last briefing. and up until now it's been a flawlessly run system.

>> well, look, they've also got to figure out exactly what they are going to say and exactly how much they are going to release. they are going to be bombarded with questions about what they know about the potential persons of interests. i hesitate to call them suspects. they haven't called them suspects yet. but how much they know, how much they want to release, do they want to solace sit help from the public in identifying who these people are? my sense is they are not there yet. that's why they are showing the photos that i'm told was being distributed tonight involves a white man with a baseball cap about six feet tall or more. now, the first blush is, do you have anything that looks like this guy? do you know anything about this person? if they don't get something fairly quickly, i think they may well go to the public and we may well be seeing this photo asking the public, have you ever seen this person?

>> michael isikoff , james calf nau, thank you both for joining me tonight.

>> thanks, lawrence.

>>> coming up, rand paul's insults to the parents of the children killed at sandy hook elementary school . you will see president obama 's response to that in his own angry words. and the mother of the 9-year-old girl who was killed in the shooting that took down gabby giffords will join me and she will also respond to what rand paul

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2ada8987/l/0Lvideo0Bmsnbc0Bmsn0N0Cid0C51578128/story01.htm

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